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One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone-Alkyne Cycloaddition Reaction

Simon Specklin, Elodie Decuypere, Lucie Plougastel, Soifia Aliani and Frédéric Taran*

*CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France, Email:

S. Specklin, E. Decuypere, L. Plougastel, S. Aliani, F. Taran, J. Org. Chem., 2014, 79, 7772-7777.

DOI: 10.1021/jo501420r


A copper-catalyzed sydnone-alkyne cycloaddition reaction offers a robust, straightforward and general method for constructing 1,4-pyrazoles from arylglycines using a three-step one-pot procedure.

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ID: J42-Y2014