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Photoredox-Induced Three-Component Azido- and Aminotrifluoromethylation of Alkenes

Guillaume Dagousset, Aude Carboni, Emmanuel Magnier* and Géraldine Masson*

*Institut Lavoisier de Versailles, Université de Versailles-Saint-Quentin, 78035 Versailles Cedex; CNRS, 91198 Gif-sur-Yvette Cedex, France, Email: emmanuel.magnieruvsq.fr, geraldine.massoncnrs.fr

G. Dagousset, A. Carboni, E. Magnier, G. Masson, Org. Lett., 2014, 16, 4340-4343.

DOI: 10.1021/ol5021477  (free Supporting Information)


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Abstract

A photoredox-catalyzed azidotrifluoromethylation of substituted styrenes as well as various activated and nonactivated alkenes using [Ru(bpy)3(PF6)2] as the photocatalyst and Umemoto's reagent as the CF3 source delivers a wide range β-trifluoromethylated azides or amines in good yields.

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Key Words

benzyl azides, alkyl azides, trifluoromethyl alkanes, photochemistry


ID: J54-Y2014