Stereoconvergent Arylations and Alkenylations of Unactivated Alkyl Electrophiles: Catalytic Enantioselective Synthesis of Secondary Sulfonamides and Sulfones
Junwon Choi, Pablo Martín-Gago and Gregory C. Fu*
*Division of Chemistry and Chemical Engineering, California
Institute of Technology, Pasadena, California 91125, United States, Email: gcfu
caltech.edu
J. Choi, P. Martín-Gago, G. C. Fu, J. Am. Chem. Soc., 2014, 136, 12161-12165.
DOI: 10.1021/ja506885s
Abstract
Ni-catalyzed stereoconvergent Negishi arylations and alkenylations of racemic α-bromosulfonamides and -sulfones furnish cross-coupling product in very good ee and yield for an array of reaction partners. Mechanistic studies are consistent with the generation of a radical intermediate.
see article for more examples
Key Words
sulfones, benzylsulfones, sulfonamides, Negishi coupling
ID: J48-Y2014
