A General Synthesis of Ynones from Aldehydes via Oxidative C-C bond Cleavage under Aerobic Conditions
Zhaofeng Wang, Li Li and Yong Huang*
*Key Laboratory of Chemical Genomics, School of Chemical
Biology and Biotechnology, Peking University, Shenzhen Graduate School,
Shenzhen, 518055, China, Email: huangyong
pkusz.edu.cn
Z. Wang, L. Li, Y. Huang, J. Am. Chem. Soc., 2014, 136, 12161-12165.
DOI: 10.1021/ja506352b
Abstract
A gold catalyst and a secondary amine work synergistically to produce trisubstituted allenyl aldehydes from readily available aldehydes and hypervalent alkynyl iodides. A subsequent oxidation leads to the desired ynone through an in situ C-C bond oxidative cleavage in the presence of molecular oxygen.
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Key Words
ID: J48-Y2014
