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Sandmeyer Trifluoromethylation

Grégory Danoun, Bilguun Bayarmagnai, Matthias F. Grünberg, Christian Matheis, Eugen Risto, Lukas J. Gooßen*

*Department of Chemistry, Technische Universität Kaiserslautern, 67663 Kaiserslautern, Germany, Email:

G. Danoun, B. Bayermagnai, M. F. Grünberg, C. Matheis, E. Risto, L. J. Gooßen, Synthesis, 2014, 46, 2283-2286.

DOI: 10.1055/s-0034-1378549

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A range of benzotrifluorides are conveniently accessible in high yields from diazonium salts and the inexpensive trifluoromethylating agent TMSCF3 through a copper-mediated Sandmeyer trifluoromethylation reaction. The combination of diazotization and trifluoromethylation in a one-pot procedure enables the trifluoromethylation of widely available (hetero)aromatic amines.

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Key Words

anilines, copper, Sandmeyer reaction, trifluoromethylation, diazonium salts

ID: J66-Y2014