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Silver-Catalyzed Radical Tandem Cyclization: An Approach to Direct Synthesis of 3-Acyl-4-arylquinolin-2(1H)-ones

Wen-Peng Mai*, Gang-Chun Sun*, Ji-Tao Wang, Ge Song, Pu Mao, Liang-Ru Yang, Jin-Wei Yuan, Yong-Mei Xiao* and Ling-Bo Qu

*Chemistry and Chemical Engineering School, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China, Email:,,

W.-P. Mai, G.-C. Sun, J.-T. Wang, G. Song, P. Mao, L.-R. Yang, J.-W. Yuan, Y.-M. Xiao, L.-B. Qu, J. Org. Chem., 2014, 79, 8094-8102.

DOI: 10.1021/jo501301t

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A silver-catalyzed method provides a practical, highly efficient, and straightforward route to substituted quinolin-2-ones or 3,4-dihydroquinolin-2-ones in one step through an intermolecular radical addition/cyclization in aqueous solution. A mechanism for the formation of quinolin-2-ones is proposed.

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Key Words

2-Quinolones, Potassium peroxydisulfate

ID: J42-Y2014