Organic Chemistry Portal



Mild Copper-TBAF-Catalyzed N-Arylation of Sulfoximines with Aryl Siloxanes

Jaeeun Kim, Jinpyo Ok, Sanghyuck Kim, Wonseok Choi and Phil Ho Lee*

*Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea, Email:

J. Kim, J. Ok, S. Kim, W. Choi, P. H. Lee, Org. Lett., 2014, 16, 4602-4603.

DOI: 10.1021/ol502174n


An efficient copper-TBAF-catalyzed arylation of sulfoximines with arylsiloxanes in dichloromethane at room temperature affords the desired N-aryl sulfoximines in good to excellent yields under an oxygen atmosphere. This mild C-N bond formation complements the existing approaches due to the advantageous properties of arylsiloxanes such as availability, low toxicity, ease of handling, high stability, and environmental benignity.

see article for more examples

Key Words

Sulfoximines, Oxygen

ID: J54-Y2014