Asymmetric Sulfa-Michael Addition to α-Substituted Vinyl Ketones Catalyzed by Chiral Primary Amine
Niankai Fu, Long Zhang, Sanzhong Luo* and Jin-Pei Cheng
*Beijing National Laboratory for Molecule Sciences (BNLMS),
Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China, Email:
luosz
iccas.ac.cn
N. Fu, L. Zhang, S. Luo, J.-P. Cheng, Org. Lett., 2014, 16, 4626-4629.
DOI: 10.1021/ol5022178
Abstract
Efficient, asymmetric conjugate addition-protonation reactions of thiols to α-substituted vinyl ketones are catalyzed by a chiral primary-tertiary diamine derived from l-phenylalanine. This organocatalyst promotes the sulfa-Michael addition-protonation reactions with good to excellent enantioselectivity.
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Key Words
Michael addition of thiols, organocatalysis
ID: J54-Y2014
