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Rhodium(III)-Catalyzed C-H Activation/Annulation with Vinyl Esters as an Acetylene Equivalent

Nicola J. Webb, Stephen P. Marsden* and Steven A. Raw

*School of Chemistry and Institute of Process Research and Development, University of Leeds, Leeds, LS2 9JT, U.K., Email: s.p.marsdenleeds.ac.uk

N. J. Webb, S. P. Marsden, S. A. Raw, Org. Lett., 2014, 16, 4716-4721.

DOI: 10.1021/ol502095z (free Supporting Information)


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Abstract

In rhodium-catalyzed C-H activation/annulation reactions for the synthesis of sixteen 3,4-unsubstituted isoquinolones, vinyl acetate emerges as a convenient acetylene equivalent. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.

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Key Words

Isoquinolones


ID: J54-Y2014