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Synthesis of N-Benzothiazol-2-yl-amides by an Iron-Catalyzed Oxidative C(sp2)-H Functionalization

Junke Wang, Yingxiao Zong*, Xuexin Zhang, Yang Gao, Zhengliang Li, Guoren Yue, Zhengjun Quan, Xicun Wang

*Key Laboratory of Hexi Corridor Resources Utilization of Gansu, College of Chemistry and Chemical Engineering, Hexi University, Zhangye 734000, P. R. of China, Email:

J. Wang, Y. Zong, X. Zhang, Y. Gao, Z. Li, G. Yuo, Z. Quan, X. Wang, Synlett, 2014, 25, 2143-2148.

DOI: 10.1055/s-0034-1378547


An iron-catalyzed oxidative cyclization of 1-acyl-3-(phenyl)thioureas in the presence of sodium persulfate gave various N-benzothiazol-2-yl-amides selectively in good yields through C(sp2)-H functionalization and C-S bond formation.

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Key Words

benzothiazoles, iron catalysis, 1-acetyl-3-phenyl­thiourea, sodium peroxydisulfate, iron(III) chloride

ID: J60-Y2014