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Synthesis of 2-Aryl/Heteroaryloxazolines from Nitriles under Metal- and Catalyst-Free Conditions and Evaluation of Their Antioxidant Activities

Parul Garg, Shweta Chaudhary and Marilyn D. Milton*

*Department of Chemistry, University of Delhi, Delhi 110 007, India, Email: mdmiltonchemistry.du.ac.in

P. Garg, S. Chaudhary, M. D. Milton, J. Org. Chem., 2014, 79, 8668-8677.

DOI: 10.1021/jo501430p (free Supporting Information)



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Abstract

The synthesis of various 2-(hetero)aryloxazolines from nitriles and aminoalcohols has been achieved without metals and catalysts in good to excellent yields. The reaction tolerates many functional groups and allows the introduction of many important biologically active motifs such as azoles, ring-fused azoles, saturated heterocyclics, and amines.

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Key Words

2-oxazolines


ID: J42-Y2014