Chemoselective Reduction of the Carbonyl Functionality through Hydrosilylation: Integrating Click Catalysis with Hydrosilylation in One Pot
Sudipta Raha Roy, Samaresh Chandra Sau and Swadhin K. Mandal*
*Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741252, India, Email: swadhin.mandaliiserkol.ac.in
S. R. Roy, S. C. Sau, S. K. Mandal, J. Org. Chem., 2014, 79, 9150-9160.
DOI: 10.1021/jo501505j (free Supporting Information)
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A chemoselective reduction of the carbonyl functionality via hydrosilylation using low loadings of a copper(I) catalyst bearing an abnormal NHC takes place at ambient temperature in excellent yield within a very short reaction time. The hydrosilylation reaction of α,β-unsaturated carbonyl compounds gives allyl alcohols in good yields. The catalyst can also be used for azide-alkyne cycloadditions.
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