Enantioselective Construction of Functionalized Cyclopentanes by a Relay Ring-Closing Metathesis and Chiral Amine (Thio)urea-Promoted Michael Addition
Yinan Zhang, Xixi Song, Xiaobei Chen, Aiguo Song, Shilei Zhang, Wei Wang*
*Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, USA, Email: wwangunm.edu
Y. Zhang, X. Song, X. Chen, A. Song, S. Zhang, W. Wang, Synthesis, 2014, 46, 2601-2607.
see article for more reactions
A relay strategy, in which ring-closing metathesis and bifunctional chiral amine (thio)urea-catalyzed Michael addition reactions proceed in a one-pot fashion, offers an alternative approach to the synthesis substituted cyclopentanes in good yields and good enantioselectivities.
see article for more examples