Organic Chemistry Portal



A Highly Active CuI/TMEDA Catalytic System for the Coupling Reaction of Acid Chlorides with Terminal Alkynes under Solvent-Free Conditions

Weiyan Yin*, Haifeng He, Yani Zhang, Di Luo, Hongwu He*

*Hubei Academy of Agricultural Science, Wuhan; College of Chemistry, Central China Normal University, Wuhan, Hubei, P. R. of China, Email:,

W. Yin, H. He, Y. Zhang, D. Luo, H. He, Synthesis, 2014, 46, 2617-2621.

DOI: 10.1055/s-0034-1378358

see article for more reactions


A highly efficient copper(I) iodide/N,N,N′,N′-tetramethylethylenediamine (CuI/TMEDA) catalytic system enables the coupling of various terminal alkynes, including 4-iodophenylacetylene, with acid chlorides to afford the corresponding ynones in very good yields in a short time. It is noteworthy that the reaction is conducted under solvent-free conditions at room temperature.

see article for more examples

Key Words

TMEDA, copper(I) iodide, ynones, acid chlorides, terminal alkynes

ID: J66-Y2014