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Direct Catalytic N-Alkylation of Amines with Carboxylic Acids

Iván Sorribes, Kathrin Junge and Matthias Beller*

*Leibniz Institute for Catalysis, University of Rostock, Albert Einstein Str. 29a, 18059 Rostock, Germany, Email:

I. Sorribes, K. Jung, M. Beller, J. Am. Chem. Soc., 2014, 136, 14314-14319.

DOI: 10.1021/ja5093612

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In a straightforward process for the N-alkylation of amines, readily available carboxylic acids and silanes as the hydride source enable an effective C-N bond construction under mild conditions and allow obtaining a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anilines as well as the bioactive compound Cinacalcet HCl.

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Key Words

reductive amination, phenylsilane

ID: J48-Y2014