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Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis

Behnaz Ghaffari, Sean M. Preshlock, Donald L. Plattner, Richard J. Staples, Peter E. Maligres, Shane W. Krska*, Robert E. Maleczka, Jr.*, and Milton R. Smith, III*

*Michigan State University, East Lansing, Michigan 48824-1322; Merck Research Laboratories, Rahway, New Jersey 07065, United States, Email: shane_krskamerck.com, maleczkachemistry.msu.edu, smithmilmsu.edu

B. Ghaffari, S. M. Preshlock, D. L. Plattner, R. J. Staples, P. E. Maligres, S. W. Krska, R. E. Maleczka, Jr., M. R. Smith, III, J. Am. Chem. Soc., 2014, 136, 14345-14348.

DOI: 10.1021/ja506229s (free Supporting Information)



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Abstract

Ir complexes with bidentate silyl ligands that contain P- or N-donors are effective catalysts for ortho borylations of a broad range of substituted aromatics. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design.

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Key Words

borylation


ID: J48-Y2014