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Copper-Catalyzed Aerobic Synthesis of 2-Arylpyridines from Acetophenones and 1,3-Diaminopropane

Long-Yi Xi, Ruo-Yi Zhang, Shuai Liang, Shan-Yong Chen* and Xiao-Qi Yu*

*Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China, Email:,

L.-Y. Xi, R.-Y. Zhang, S. Liang, S.-Y. Chen, X.-Q. Yu, Org. Lett., 2014, 16, 5269-5271.

DOI: 10.1021/ol5023596

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A copper-catalyzed reaction of acetophenones and 1,3-diaminopropane provides direct access to 2-arylpyridines. A range of electronically diverse acetophenones undergo this transformation, affording 2-arylpyridines in good yields.

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Key Words

pyridines, oxygen

ID: J54-Y2014