Organic Chemistry Portal



PCN Pincer Palladium(II) Complex Catalyzed Enantioselective Hydrophosphination of Enones: Synthesis of Pyridine-Functionalized Chiral Phosphine Oxides as NCsp3O Pincer Preligands

Xin-Qi Hao, Juan-Juan Huang, Tao Wang, Jing Lv, Jun-Fang Gong* and Mao-Ping Song*

*Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450001, People's Republic of China, Email:,

X.-Q. Hao, J.-J. Huang, T. Wang, J. Lv, J.-F. Gong, M.-P. Song, J. Org. Chem., 2014, 79, 9512-9530.

DOI: 10.1021/jo5015307 (free Supporting Information)


Chiral PCN pincer Pd(II) complexes were examined as enantioselective catalysts for the hydrophosphination of enones. Hydrophosphination of 2-alkenoylarenes with diphenylphosphine followed by oxidation with hydrogen peroxide afforded the corresponding chiral phosphine oxides in good yields with very good enantioselectivities.

see article for more examples

Key Words

phosphine oxides

ID: J42-Y2014