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PCN Pincer Palladium(II) Complex Catalyzed Enantioselective Hydrophosphination of Enones: Synthesis of Pyridine-Functionalized Chiral Phosphine Oxides as NCsp3O Pincer Preligands

Xin-Qi Hao, Juan-Juan Huang, Tao Wang, Jing Lv, Jun-Fang Gong* and Mao-Ping Song*

*Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450001, People's Republic of China, Email: gongjfzzu.edu.cn., mpsongzzu.edu.cn

X.-Q. Hao, J.-J. Huang, T. Wang, J. Lv, J.-F. Gong, M.-P. Song, J. Org. Chem., 2014, 79, 9512-9530.

DOI: 10.1021/jo5015307 (free Supporting Information)


Abstract

Chiral PCN pincer Pd(II) complexes were examined as enantioselective catalysts for the hydrophosphination of enones. Hydrophosphination of 2-alkenoylarenes with diphenylphosphine followed by oxidation with hydrogen peroxide afforded the corresponding chiral phosphine oxides in good yields with very good enantioselectivities.

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Key Words

phosphine oxides


ID: J42-Y2014