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Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters

Yunbo Zhu, Long Zhang and Sanzhong Luo*

*Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: Luosziccas.ac.cn

Y. Zhu, L. Zhang, S. Luo, J. Am. Chem. Soc., 2014, 136, 14642-14645.

DOI: 10.1021/ja508605a (free Supporting Information)


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Abstract

The merger of photoredox catalysis and primary amine catalysis enables a direct construction of all-carbon quaternary stereocenters via α-photoalkylation of β-ketocarbonyls with high efficacy and enantioselectivities.

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Key Words

active methylenes, 1,4-diketones


ID: J48-Y2014