Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters
Yunbo Zhu, Long Zhang and Sanzhong Luo*
*Beijing National Laboratory for Molecule Sciences (BNLMS),
CAS Key Laboratory for Molecular Recognition and Function, Institute of
Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email:
Luosz
iccas.ac.cn
Y. Zhu, L. Zhang, S. Luo, J. Am. Chem. Soc., 2014, 136, 14642-14645.
DOI: 10.1021/ja508605a
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Abstract
The merger of photoredox catalysis and primary amine catalysis enables a direct construction of all-carbon quaternary stereocenters via α-photoalkylation of β-ketocarbonyls with high efficacy and enantioselectivities.
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Key Words
active methylenes, 1,4-diketones
ID: J48-Y2014
