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Direct Oxidative Coupling of Enamines and Electron-Deficient Amines: TBAI/TBHP-Mediated Synthesis of Substituted Diaminoalkenes under Metal-Free Conditions

Yucheng Yuan, Wenjuan Hou, Daisy Zhang-Negrerie, Kang Zhao and Yunfei Du*

*School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China, Email:

Y. Yuan, W. Hou, D. Zhang-Negrerie, K. Zhaou, Y. Du, Org. Lett., 2014, 16, 5410-5113.

DOI: 10.1021/ol5026525

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TBAI as catalyst and TBHP as oxidant enable a metal-free cross-coupling of enamines and electron-deficient amines through oxidative C(sp2)-N bond formation. This efficient organocatalytic synthesis of synthetically useful diaminoalkene derivatives features readily available starting materials and wide substrate scope.

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Key Words

α-Ketoenamines, Imides, TBHP

ID: J54-Y2014