Organic Chemistry Portal



Facile One-Pot Synthesis of Benzimidazole and Quinoxalin-2(1H)-one Scaffolds via Two-Component Coupling Reaction, Deprotection, and Intermolecular Cyclization

Zhong-Zhu Chen, Ying Tang, Lei Zuo, Dian-Yong Tang, Jin Zhang*, Zhi-Gang Xu*

*Drug Discovery Center of Innovation, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing 402160, P. R. of China, Email:,

Z.-Z. Chen, Y. Tang, L. Zuo, D.-Y. Tang, J. Zhang, Z.-G. Xu, Synlett, 2014, 25, 2518-2520.

DOI: 10.1055/s-0034-1379016 (free Supporting Information)

see article for more reactions


Benzimidazoles and quinoxalin-2(1H)-ones were synthesized by treatment of 2-(N-Boc-amino)phenyl­isocyanide with carboxylic acids and glyoxylic acids, respectively via two-component coupling, deprotection, and intermolecular cyclization.

see article for more examples

Key Words

microwave synthesis, benzimidazoles, quinoxaline-2(1H)-ones, quinoxalinones, two-component coupling, one-pot synthesis, intermolecular cyclization

ID: J60-Y2014