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Phenazinium Salt-Catalyzed Aerobic Oxidative Amidation of Aromatic Aldehydes

Dasheng Leow*

*Department of Chemistry, National Tsing Hua University, 101, Sec 2, Kuang-Fu Road, Hsinchu 30013, Taiwan, R.O.C., Email:

D. Leow, Org. Lett., 2014, 16, 5812-5815.

DOI: 10.1021/ol5029354 (free Supporting Information)


An oxidative amidation of aromatic aldehydes in the presence of low loadings of phenazine ethosulfate as an inexpensive metal-free visible light photocatalyst proceeds at ambient temperature and uses air as the sole oxidant. The operationally easy procedure provides an economical, green, and mild alternative for the formation of amide bonds.

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Key Words

Oxidative Amidation, Oxygen

ID: J54-Y2014