Gallium-Catalyzed Reductive Chlorination of Carboxylic Acids with Copper(II) Chloride

Norio Sakai*, Takumi Nakajima, Shinichiro Yoneda, Takeo Konakahara and Yohei Ogiwara

*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan, Email: sakachemrs.noda.tus.ac.jp

N. Sakai, T. Nakajima, S. Yoneda, T. Konakahara, Y. Ogiwara, J. Org. Chem., 2014, 79, 10619-10623.

DOI: 10.1021/jo501912v

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Abstract

The counteranions of CuCl₂ functioned as a chloride source in a reductive chlorination of carboxylic acids in the presence of a gallium(III) catalyst and a hydrosiloxane.

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Key Words

alkyl chlorides, TMDS

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ID: J42-Y2014