Enantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis
John R. Coombs, Liang Zhang and James P. Morken*
*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States, Email: morkenbc.edu
J. R. Coombs, L. Zhang, J. P. Morken, J. Am. Chem. Soc., 2014, 136, 16140-16143.
see article for more reactions
A catalytic enantioselective diboration of vinyl boronate esters furnishes chiral tris(boronates). Subsequent intermolecular or intramolecular deborylative alkylation occurs in a diastereoselective fashion.
see article for more examples
Pt-Catalyzed Enantioselective Diboration of Terminal Alkenes with B2(pin)2
L. T. Kliman, S. N. Mlynarski, J. P. Morken, J. Am. Chem. Soc., 2009, 131, 13210-13211.
alkyl boronates, alkylation, dihydroxylation