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Palladium-Catalyzed Sequential C-N/C-O Bond Formations: Synthesis of Oxazole Derivatives from Amides and Ketones

Meifang Zheng, Liangbin Huang, Huawen Huang, Xianwei Li, Wanqing Wu and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email:

M. Zhang, L. Huang, H. Huang, X. Li, W. Wu, H. Jiang, Org. Lett., 2014, 16, 5906-5909.

DOI: 10.1021/ol502916a

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A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones proceeds through a C-N bond formation followed by a C-O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medicinal chemistry.

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Key Words

oxazoles, potassium peroxydisulfate

ID: J54-Y2014