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Transition Metal-Mediated C=O and C=C Bond-Forming Reactions: A Regioselective Strategy for the Synthesis of Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrazines

Hua Cao*, Xiaohang Liu, Jinqiang Liao, Jianping Huang, Huifang Qiu, Qinlin Chen and Yaoyi Chen

*School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China, Email:

H. Cao, X. Liu, J. Liaou, J. Huang, H. Qiu, Q. Chen, Y. Chen, J. Org. Chem., 2014, 79, 11209-11214.

DOI: 10.1021/jo501671x (free Supporting Information)

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Copper(I)- and palladium(II)-catalyzed cyclizations enable a convenient synthesis of functionalized imidazo[1,2-a]pyridine aldehydes/ketones and 3-vinyl imidazo[1,2-a]pyridines. These one-pot reactions proceed smoothly with commercially available catalysts and afford the products in good yields.

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ID: J42-Y2014