Organic Chemistry Portal



Facile Palladium-Catalyzed Hydrocarboxylation of Olefins without External CO Gas

Yang Wang, Wenlong Ren, Jingfu Li, Haining Wang and Yian Shi*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email:

Y. Wang, W. Ren, J. Li, H. Wang, Y. Shi, Org. Lett., 2014, 16, 5960-5963.

DOI: 10.1021/ol502987f (free Supporting Information)

see article for more reactions


Using an effective Pd-catalyzed hydrocarboxylation of olefins with phenyl formate and formic acid, various carboxylic acids are obtained in good yields with high regioselectivities under operationally simple conditions in the absence of toxic CO gas.

see article for more examples

A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

W. Liu, W. Ren, J. Li, Y. Shi, W. Chang, Y. Shi, Org. Lett., 2017, 19, 1748-1751.

An Effective Pd-Catalyzed Regioselective Hydroformylation of Olefins with Formic Acid

W. Ren, W. Chang, J. Dai, Y. Shi, J. Li, Y. Shi, J. Am. Chem. Soc., 2016, 138, 14864-14867.

Pd-Catalyzed Regiodivergent Hydroesterification of Aryl Olefins with Phenyl Formate

W. Ren, W. Chang, Y. Wang, J. Li, Y. Shi, Org. Lett., 2015, 17, 3544-3547.

Key Words

carboxylic acids

ID: J54-Y2014