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A Novel Ruthenium-Catalyzed Dehydrogenative Synthesis of 2-Arylquinazolines from 2-Aminoaryl Methanols and Benzonitriles

Mengmeng Chen, Min Zhang*, Biao Xiong, Zhenda Tan, Wan Lv and Huanfeng Jiang

*School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, People’s Republic of China, Email:

M. Chen, M. Zhang, B. Xiong, Z. Tan, W. Lv, H. Jiang, Org. Lett., 2014, 16, 6028-6031.

DOI: 10.1021/ol503052s (free Supporting Information)

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A commercially available Ru3(CO)12/Xantphos/t-BuOK catalyst system enables a straightforward ruthenium-catalyzed dehydrogenative synthesis of 2-arylquinazolines. Various 2-aminoaryl methanols were efficiently converted in combination with different types of benzonitriles into the desired products in good yields. The synthetic protocol offers operational simplicity, high atom efficiency and broad substrate scope.

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ID: J54-Y2014