Tandem Synthesis of 3-Halo-5-Substituted Isoxazoles from 1-Copper(I) Alkynes and Dihaloformaldoximes
Wenwen Chen, Bo Wang, Nan Liu, Dayun Huang, Xinyan Wang* and Yuefei Hu*
*Department of Chemistry, Tsinghua University, Beijing
100084, P. R. China, Email: wangxinyan
mail.tsinghua.edu.cn,
yfhmail.tsinghua.edu.cn
W. Chen, B. Wang, N. Liu, D. Huang, X. Wang, Y. Hu, Org. Lett., 2014, 16, 6140-6143.
DOI: 10.1021/ol503008t
Abstract
A tandem synthesis of 3-halo-5-substituted isoxazoles from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions circumvents 1,3-dipolar cycloaddition and all its drawbacks.
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Key Words
ID: J54-Y2014
