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Iminopyridine Oxazoline Iron Catalyst for Asymmetric Hydroboration of 1,1-Disubtituted Aryl Alkenes

Jianhui Chen, Tuo Xi and Zhan Lu*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, China, Email:

J. Chen, T. Xi, Z. Lu, Org. Lett., 2014, 16, 6452-6455.

DOI: 10.1021/ol503282r


A novel chiral iminopyridine oxazoline (IPO) ligand enables a highly regio- and enantioselective iron-catalyzed anti-Markovnikov hydroboration of 1,1-disubstituted aryl alkenes. This distinct class of reactive IPO ligands will likely be of high value for a large variety of asymmetric transformations using first-row transition metals.

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ID: J54-Y2014