Cyanation of Unactivated Aryl Chlorides and Aryl Mesylates Catalyzed by Palladium and Hemilabile MOP-Type Ligands
Yahui Tu, Yi Zhang, Sheng Xu, Zhaoguo Zhang, Xiaomin Xie*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China, Email: xiaominxiesjtu.edu.cn
Y. Tu, Y. Zhang, S. Xu, Z. Zhang, X. Xie, Synlett, 2014, 25, 2938-2942.
Hemilabile, bulky, and electron-rich MOP-type ligands enable a highly efficient palladium-catalyzed cyanation of unactivated aryl chlorides and even aryl mesylates with potassium hexacyanoferrate in good yields using t-BuOH and H2O as the solvent and K2CO3 as the base.
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palladium, monophosphine ligands, cyanation, aryl chlorides, aryl mesylates