Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles
Lei Zhu, Yinghua Yu, Zhifeng Mao and Xueliang Huang*
*State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155#, Fuzhou, Fujian, China, 350002, Email: huangxlfjirsm.ac.cn
L. Zhu, Y. Yu, Z. Mao, X. Huang, Org. Lett., 2015, 17, 30-33.
DOI: 10.1021/ol503172h (free Supporting Information)
see article for more reactions
An effective and mild gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides provides highly substituted pyrroles in a straightforward manner in very good yields. Preliminary results indicate that a nongold carbenoid pathway is preferred.
see article for more examples
Y. Wu, L. Zhu, Y. Yu, X. Luo, X. Huang, J. Org. Chem., 2015, 80, 11407-11416.