Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from o-Iodoanilines, Isocyanide, and Potassium Sulfide
Pan Dang, Weilan Zeng and Yun Liang*
*Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, Hunan 410081, China, Email: ylianghunnu.edu.cn
P. Dang, W. Zeng, Y. Liang, Org. Lett., 2015, 17, 34-37.
DOI: 10.1021/ol503186w (free Supporting Information)
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In the presence of CuCl, a three-component reaction of o-iodoanilines and K2S with TosMIC proceeded smoothly to yield the corresponding benzothiazolethiones in very good yields. Notably, isocyanide served as a carbon source and K2S functioned as a sulfur source.
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