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Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from o-Iodoanilines, Isocyanide, and Potassium Sulfide

Pan Dang, Weilan Zeng and Yun Liang*

*Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha, Hunan 410081, China, Email:

P. Dang, W. Zeng, Y. Liang, Org. Lett., 2015, 17, 34-37.

DOI: 10.1021/ol503186w

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In the presence of CuCl, a three-component reaction of o-iodoanilines and K2S with TosMIC proceeded smoothly to yield the corresponding benzothiazolethiones in very good yields. Notably, isocyanide served as a carbon source and K2S functioned as a sulfur source.

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Key Words

benzo-fused N-Heterocycles, benzo-fused S-heterocycles, Multicomponent Reactions

ID: J54-Y2015