Synthesis of α-Methylene-β-Lactams via PPh3-Catalyzed Umpolung Cyclization of Propiolamides
Lin Zhu, Yan Xiong and Chaozhong Li*
*Shanghai Institute of Organic Chemistry, Chinese Academy of
Sciences, 345 Lingling Road, Shanghai 200032, P. R. China, Email: clig
mail.sioc.ac.cn
L. Zhu, Y. Xiong, C. Li, J. Org. Chem., 2015, 80, 628-633.
DOI: 10.1021/jo502265a
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Abstract
Umpolung enables a facile synthesis of α-methylene-β-lactams. Under the catalysis of triphenylphosphine, a number of 2-propiolamidoacetates or α-propiolamido ketones underwent cyclization to afford the corresponding 4-substituted 3-methyleneazetidin-2-ones in high yields.
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Key Words
ID: J42-Y2015
