Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
Daniel T. Cohen and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu
D. T. Cohen, S. L. Buchwald, Org. Lett., 2015, 17, 202-205.
DOI: 10.1021/ol5032359 (free Supporting Information)
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A mild and efficient, palladium-catalyzed reaction allows the cyanation of a wide range of (hetero)aryl halides and triflates at low catalyst loadings with mild temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.
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