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Practical Route to 2-Quinolinones via a Pd-Catalyzed C-H Bond Activation/C-C Bond Formation/Cyclization Cascade Reaction

Junliang Wu, Shaohua Xiang, Jing Zeng, Minli Leow and Xue-Wei Liu*

*Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Email:

J. Wu, S. Xiang, J. Zeng, M. Leow, X.-W. Liu, Org. Lett., 2015, 17, 222-225.

DOI: 10.1021/ol503292p


A Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade process enables the synthesis of quinolinone derivatives from simple anilines as the substrates. This method provides access to quinolinone-containing alkaloids and drug molecules.

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Key Words

2-Quinolones, Sodium peroxydisulfate

ID: J54-Y2015