Organic Chemistry Portal



Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides

Adam Noble, Stefan J. McCarver and David W. C. MacMillan*

*Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States, Email:

A. Noble, S. J. McCarver, D. W. C. MacMillan, J. Am. Chem. Soc., 2015, 137, 624-627.

DOI: 10.1021/ja511913h

see article for more reactions


The synergistic merger of photoredox and nickel catalysis enables a decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides. Various α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids and a broad range of vinyl iodides and bromides can be converted to vinylation products in high efficiency under mild, operationally simple reaction conditions.

see article for more examples


Key Words


ID: J48-Y2015