Organic Chemistry Portal



Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides in Water

Yi-An Chen, Satpal Singh Badsara, Wan-Ting Tsai, Chin-Fa Lee*

*Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, R. O. C., Email:

Y.-A. Chen. S. S. Badsara, W.-T. Tsai, C.-F. Lee, Synthesis, 2015, 47, 181-186.

DOI: 10.1055/s-0034-1379206

see article for more reactions


A combination of copper(II) oxide and 1,10-phenanthroline catalyzes a microwave-promoted C-S bond formation of thiols and aryl iodides. Various aryl iodides react smoothly with thiols to provide the corresponding aryl sulfides in very good yields in water with a short reaction time. Amino, chloro, bromo, acetyl, and nitro groups are tolerated.

see article for more examples

Key Words

microwave synthesis, copper, cross-coupling, thiols, aryl iodides, sulfides

ID: J66-Y2015