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Copper-Catalyzed Synthesis of Substituted Quinolines via C-N Coupling/Condensation from ortho-Acylanilines and Alkenyl Iodides

Lingkai Kong, Yuanyuan Zhou, He Huang, Yang Yang, Yuanyuan Liu* and Yanzhong Li*

*Department of Chemistry, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China, Email:,

J. Zheng, L. Huang, C. Huang, W. Wu, H. Jiang, J. Org. Chem., 2015, 80, 1235-1242.

DOI: 10.1021/jo502630t

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In an efficient cascade copper-catalyzed intermolecular Ullmann-type C-N coupling/enamine condensation reaction, ortho-acylanilines and alkenyl iodides are converted to multisubstituted quinolines in very good yields.

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Key Words


ID: J42-Y2015