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Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides

Sheng-Chun Sha, Jiadi Zhang and Patrick J. Walsh*

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States, Email:

S.-C. Sha, J. Zhang, P. J. Walsh, Org. Lett., 2015, 17, 410-413.

DOI: 10.1021/ol503545j (free Supporting Information)

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A palladium-catalyzed deprotonative cross-coupling process (DCCP) enables a γ-arylation of aryl acetic acids with wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described.

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Key Words


ID: J54-Y2015