Asymmetric α-Benzoyloxylation of β-Ketocarbonyls by a Chiral Primary Amine Catalyst
Dehong Wang, Changming Xu, Long Zhang, and Sanzhong Luo*
*Beijing National Laboratory for Molecular Sciences (BNLMS),
CAS Key Laboratory of Molecular Recognition and Function, Institute of
Chemistry, Chinese Academy of Sciences, Beijing, 100190, China, Email:
luosz
iccas.ac.cn
D. Wang, C. Xu, L. Zhang, S. Luo, Org. Lett., 2015, 17, 576-579.
DOI: 10.1021/ol503592n
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Abstract
The direct asymmetric α-benzoyloxylation of β-ketocarbonyls catalyzed by a chiral primary amine demonstrates excellent enantioselectivity for a broad range of substrates, which allows convenient access to highly enantioenriched α-hydroxy-β-ketocarbonyls.
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Key Words
hydroxylation, benzoyl peroxide, organocatalysis
ID: J54-Y2015
