Applications of α-Phosphonovinyl Tosylates in the Synthesis of α-Arylethenylphosphonates via Suzuki-Miyaura Cross-Coupling Reactions
Yewen Fang*, Li Zhang, Jinjian Li, Xiaoping Jin*, Meijuan Yuan, Ruifeng Li*, Rong Wu and Jianghua Fang
*Ningbo University of Technology, Ningbo 315016; Taiyuan University of Technology, Taiyuan 030024; Zhejiang Pharmaceutical College, Ningbo 315100, China, Email: fangnbut.edu.cn, xiaop.jingmail.com, rflityut.edu.cn
Y. Fang, L. Zhang, J. Li, X. Jin, M. Yuan, R. Li, R. Wu, J. Fang, Org. Lett., 2015, 17, 798-801.
DOI: 10.1021/ol503518h (free Supporting Information)
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α-Phosphonovinyl tosylates can be coupled efficiently with a range of arylboronic acids to provide α-arylethenylphosphonates. The unprecedented procedure exhibits excellent functional group tolerance, giving the terminal vinylphosphonates in good to excellent isolated yields under mild reaction conditions.
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Y. Fang, L. Zhang, X. Jin, J. Li, M. Yuan, R. Li, H. Gao, J. Fang, Y. Liu, Synlett, 2015, 26, 980-984.