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POCl3-Mediated Reaction of 1-Acyl-1-carbamoyl Oximes: A New Entry to Cyanoformamides

Jiming Yang, Dexuan Xiang, Rui Zhang, Ning Zhang*, Yongjiu Liang and Dewen Dong*

*Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China, Email:,

J. Yang, D. Xiang, R. Zhang, Y. Liang, D. Dong, Org. Lett., 2015, 17, 809-811.

DOI: 10.1021/ol503643p


A facile and efficient one-pot reaction enables the synthesis of cyanoformamides from readily available 1-acyl-1-carbamoyl oximes in the presence of phosphoryltrichloride under mild conditions in very good yields.

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ID: J54-Y2015