A Synthetic Approach to N-Aryl Carbamates via Copper-Catalyzed Chan-Lam Coupling at Room Temperature
Soo-Yeon Moon, U. Bin Kim, Dan-Bi Sung and Won-Suk Kim*
*Department of Chemistry and Nano Science, Ewha Womans
University, Seoul 120-750, South Korea, Email: wonsukk
ewha.ac.kr
S.-Y. Moon, U. Bin Kim, D.-B. Sung, W.-S. Kim, J. Org. Chem., 2015, 80, 1856-1865.
DOI: 10.1021/jo502828r
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Abstract
The reaction of azidoformates with boronic acids in the presence of 10 mol% of copper chloride enables a mild and efficient synthesis of N-arylcarbamates in an open flask at room temperature without additional base, ligand, or additive. A subsequent reaction with aluminum-amine complexes in a two-step one-pot procedure gives N-arylcarbamates.
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Key Words
Carbamates, Chan-Lam Coupling, Anilines
ID: J42-Y2015
