Organic Chemistry Portal

Abstracts

Search:

Nickel-NHC-Catalyzed Cross-Coupling of 2-Methylsulfanylbenzofurans with Alkyl Grignard Reagents

Alexandre Baralle, Shinya Otsuka, Vincent Guérin, Kei Murakami, Hideki Yorimitsu*, Atsuhiro Osuka

*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan, Email: yorikuchem.kyoto-u.ac.jp

A. Baralle, S. Otsuka, V. Guérin, K. Murakami, H. Yorimitsu, A. Osuka, Synlett, 2015, 26, 327-330.

DOI: 10.1055/s-0034-1378914 (free Supporting Information)


see article for more reactions

Abstract

NiCl2(PPh3)(IPr) catalyzes cross-coupling reactions of 2-methylsulfanylbenzofurans with alkyl Grignard reagents. The alkylation is widely applicable, including the synthesis of a couple of protein tyrosine phosphatase inhibitors, 3-(4-biphenylyl)-2-alkylbenzofurans.

see article for more examples



Key Words

nickel, alkylation, benzofurans, cross-coupling, sulfide, homogeneous catalysis


ID: J60-Y2015