Nickel-NHC-Catalyzed Cross-Coupling of 2-Methylsulfanylbenzofurans with Alkyl Grignard Reagents

Alexandre Baralle, Shinya Otsuka, Vincent Guérin, Kei Murakami, Hideki Yorimitsu*, Atsuhiro Osuka

*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan, Email: yorikuchem.kyoto-u.ac.jp

A. Baralle, S. Otsuka, V. Guérin, K. Murakami, H. Yorimitsu, A. Osuka, Synlett, 2015, 26, 327-330.

DOI: 10.1055/s-0034-1378914

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Abstract

NiCl₂(PPh₃)(IPr) catalyzes cross-coupling reactions of 2-methylsulfanylbenzofurans with alkyl Grignard reagents. The alkylation is widely applicable, including the synthesis of a couple of protein tyrosine phosphatase inhibitors, 3-(4-biphenylyl)-2-alkylbenzofurans.

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Key Words

nickel, alkylation, benzofurans, cross-coupling, sulfide, homogeneous catalysis

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ID: J60-Y2015