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A Simple and Efficient Synthesis of 3,4,5-Trisubstituted/N-Fused 1,2,4-Triazoles via Ceric Ammonium Nitrate Catalyzed Oxidative Cyclization of Amidrazones with Aldehydes Using Polyethylene Glycol as a Recyclable Reaction Medium

Mangarao Nakka, Ramu Tadikonda, Srinuvasarao Rayavarapu, Prasanthi Sarakula, Siddaiah Vidavalur*

*Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam - 530 003, India, Email:

M. Nakka, R. Tadikonda, S. Rayavarapu, P. Sarakula, S. Vidavalur, Synthesis, 2015, 47, 517-525.

DOI: 10.1055/s-0034-1378909

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An environmentally benign synthesis of various 3,4,5-trisubstituted 1,2,4-triazoles and N-fused 1,2,4-triazoles via ceric ammonium nitrate catalyzed oxidative cyclization of amidrazones and aldehydes using polyethylene glycol as recyclable reaction medium is economic and potentially viable for commercial applications.

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Key Words

polyethylene glycol, CAN, 4H-1,2,4-triazoles, 1,2,4-triazolo[4,3-a]pyridines, [1,2,4]triazolo[4,3-a]pyrazines

ID: J66-Y2015