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Copper-Catalyzed Oxidative Amination of sp3 C-H Bonds under Air: Synthesis of 1,3-Diarylated Imidazo[1,5-a]pyridines

Huiqiao Wang, Wentao Xu, Zhiqiang Wang, Lintao Yu and Kun Xu*

*College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, P. R. China, Email: xukunnynu.edu.cn

H. Wang, W. Xu, Z. Wang, L. Yu, K. Xu, J. Org. Chem., 2015, 80, 1856-1865.

DOI: 10.1021/jo5027723


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Abstract

A copper(II)-catalyzed tandem reaction between pyridine ketone and benzylamine proceeded via an efficient condensation-amination-oxidative dehydrogenation process, affording 1,3-diarylated imidazo[1,5-a]pyridines in excellent yields using clean O2 as an oxidant.

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Synthesis of 1,3-Disubstituted Imidazo[1,5-a]pyridines from Amino Acids via Catalytic Decarboxylative Intramolecular Cyclization

H. Wang, W. Xu, L. Xin, W. Liu, Z. Wang, K. Xu, J. Org. Chem., 2016, 81, 3681-3687.


Key Words

Imidazo[1,5-a]pyridines, Oxygen


ID: J42-Y2015