Organic Chemistry Portal



Microwave-Assisted Catalyst-Free Synthesis of Substituted 1,2,4-Triazoles

Ganesh M. Shelke, V. Kameswara Rao, Mukund Jha, T. Stan Cameron, Anil Kumar*

*Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031, India, Email:

G. M. Shelke, V. K. Rao, M. Jha, T. S. Cameron, A. Kumar, Synlett, 2015, 26, 404-407.

DOI: 10.1055/s-0034-1379734 (free Supporting Information)


A simple, efficient, and mild method for the synthesis of substituted 1,2,4-triazoles from hydrazines and formamide proceeds smoothly under microwave irradiation in the absence of a catalyst and shows excellent functional-group tolerance.

see article for more examples

Key Words

microwave, microwave-assisted organic synthesis, 1,2,4-triazoles, aryl hydrazines, formamide

ID: J60-Y2015