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Copper-Catalyzed Synthesis of Weinreb Amides by Oxidative Amidation of Alcohols

Subhash L. Yedage, Bhalchandra M. Bhanage*

*Department of Chemistry, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai 400 019, India, Email:

S. L. Yedage, B. M. Bhanage, Synthesis, 2015, 47, 526-532.

DOI: 10.1055/s-0034-1379583

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The use of tert-butyl hydroperoxide as an oxidant and an inexpensive and air stable copper catalyst enables a simple and efficient protocol for the oxidative amidation of commercially affordable alcohols to Weinreb amides in very good yields. The reaction tolerates various functional groups.

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Key Words

alcohols, amides, copper, oxidative amidation, Weinreb amides, cross-coupling, TBHP

ID: J66-Y2015