Copper-Catalyzed Synthesis of Weinreb Amides by Oxidative Amidation of Alcohols
Subhash L. Yedage, Bhalchandra M. Bhanage*
*Department of Chemistry, Institute of Chemical Technology,
N. Parekh Marg, Matunga, Mumbai 400 019, India, Email: bm.bhanage
ictmumbai.edu.in
S. L. Yedage, B. M. Bhanage, Synthesis, 2015, 47, 526-532.
DOI: 10.1055/s-0034-1379583
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Abstract
The use of tert-butyl hydroperoxide as an oxidant and an inexpensive and air stable copper catalyst enables a simple and efficient protocol for the oxidative amidation of commercially affordable alcohols to Weinreb amides in very good yields. The reaction tolerates various functional groups.
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Key Words
alcohols, amides, copper, oxidative amidation, Weinreb amides, cross-coupling, TBHP
ID: J66-Y2015
