Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O-Acetals
Liyin Jiang, Tao Jia, Min Wang, Jian Liao and Peng Cao*
*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China, Email: caopengcib.ac.cn
L. Jiang, T. Jia, M. Wang, J. Liao, P. Cao, Org. Lett., 2015, 17, 1070-1073.
DOI: 10.1021/acs.orglett.5b00146 (free Supporting Information)
A Pd-catalyzed asymmetric intermolecular hydroalkoxylation of allenes with phenol as a pronucleophile gives acyclic O,O-acetals in high yields with very good enantiomeric excesses.
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