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Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O-Acetals

Liyin Jiang, Tao Jia, Min Wang, Jian Liao and Peng Cao*

*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China, Email: caopengcib.ac.cn

L. Jiang, T. Jia, M. Wang, J. Liao, P. Cao, Org. Lett., 2015, 17, 1070-1073.

DOI: 10.1021/acs.orglett.5b00146 (free Supporting Information)


Abstract

A Pd-catalyzed asymmetric intermolecular hydroalkoxylation of allenes with phenol as a pronucleophile gives acyclic O,O-acetals in high yields with very good enantiomeric excesses.


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Key Words

acetals


ID: J54-Y2015